Pharmacokinetics Vs. Pharmacodynamics: The Key Differentiator


Clinical pharmacology is the study of medication interactions with the human body. This research is further subdivided into two sections: Pharmacokinetics and Pharmacodynamics. These clinical trials are conducted to understand better the efficacy and safety of medications on the human body. 

pharmacokinetics vs pharmacodynamics the primary distinction between these two studies is that Pharmacokinetics (commonly known as PK) describes “what the body does to the medication,” whereas Pharmacodynamics (also known as PD) describes “what the drug does to the body.” The term “kinetic” (which means movement) in Pharmacokinetics can define PK as the drug movement through the body’s circulation system and out of it. The term “dynamic” (which means power or energy) can also be used to define Pharmacodynamics as how drugs exert their control over the human body. These can study under sad mad study and mad clinical trials.

The study of a drug’s absorption, distribution, metabolism, and excretion, also called its ADME properties, is a part of Pharmacokinetics. At the same time, the study of the biochemical and physiologic impact of a drug and its organ-specific mechanism of action on a cellular level is called Pharmacodynamics.

The PK and PD can be described as the exposure-response relationship between the prescribed drug and the human body. PK explains a drug’s reaction in terms of biochemical or molecular interactions, whereas PD depicts the drug’s exposure in terms of its ADME features.

PK assay bioanalytical testing procedures are used to evaluate metabolites in sample fluids such as urine, saliva, plasma, and so on, as well as information on the drug’s temporal profile. PD biomarkers are employed in the investigation of Parkinson’s disease. They are biological markers that can be directly evaluated and offer an overview of target interactions and proof of concept, i.e., the amount of a drug’s natural impact.

PK offers the clinical data foundation upon which evaluations of the time course of a particular drug concentration and its effects on the body are formed. At the same time, PD clinical data provides information regarding the intensity of a drug effect about its concentration in the body fluid. Based on all these factors, pk drug and pk samples are researched, and the development process is initiated.

Both of the PK/PD analyses provide Dose-response curves. For Pharmacokinetics, it is drug concentration versus time curve, whereas, for Pharmacodynamics, it is drug effect versus time curve.

The PD/PK data makes up 25% of the information written on the labels of the clinical drugs. The clinicians use this information to prescribe a particular amount of dosage and its drug’s course duration to different patients (from children to the elderly). PK and PD analysis are the cornerstones of drug developments in other nations. Drug developers use this information to construct better clinical studies. Detailed information  clinically verified about the effects and efficiency in a time-specific manner provides a foundation for further developments and improvements. Accuracy in both pharmacodynamics and pharmacokinetics services is essential for further progress in the global medical sciences community.

Layla Bella

Layla Bella is an independent writer, reader, designer, digital marketer and experienced blogger. She help companies, entrepreneurs, freelancers, students and new startups to grow digitally. She is passionate about reading non-fiction, geek TV shows, and steam online gaming.

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